Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
8
Quercetin shows promise for cholesterol
We explored how quercetin affects heart health in rats with high cholesterol. The study found that quercetin significantly improved lipid profiles and reduced oxidative stress linked to high-cholesterol diets.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
Read More
Most Useful Reviews
7.5
Reduces cholesterol risk
8 people found this helpful
Quercetin is an excellent antioxidant. I took it on my doctor's advice. It protects the brain and heart from damage due to insufficient blood supply, especially with high blood pressure. Quercetin lowers the risk of chronic vascular diseases and helps reduce high cholesterol. My cardiologist recommended it for my mother after her heart attack, and she’s advised to take it twice a year.
Read More
7.5
Eliminates skipped beats
5 people found this helpful
This supplement has been a tremendous blessing. No more skipped heartbeats, and it may help lower my high cholesterol as well.
Read More
7.5
Effective for cholesterol
3 people found this helpful
Quercetin, found in many fruits and vegetables, has been beneficial for me. I've been taking it for over a year, with my recent tests showing decreased LDL cholesterol, blood sugar, and blood pressure. I will continue as it has positively impacted my high cholesterol.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We examined the effects of a berry extract from Lonicera caerulea, rich in polyphenols, on high cholesterol levels. In laboratory tests with Caco-2 cells and rats, the extract proved effective in reducing cholesterol levels and boosting antioxidant capacity.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
Read More
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We examined the effects of quercetin nanoemulsion (QT+NE) on cholesterol levels and muscle function in mice on a high-fat diet. Over 11 weeks, QT+NE showed a notable reduction in body weight gain and improved fat distribution when compared to a high-fat diet alone.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
Read More
8
We investigated how Massa Medicata Fermentata (MMF), which contains quercetin, impacts cholesterol and overall metabolic health. In our study, zebrafish were fed a high-cholesterol diet while receiving MMF for three weeks.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduces cholesterol risk
8 people found this helpful
Quercetin is an excellent antioxidant. I took it on my doctor's advice. It protects the brain and heart from damage due to insufficient blood supply, especially with high blood pressure. Quercetin lowers the risk of chronic vascular diseases and helps reduce high cholesterol. My cardiologist recommended it for my mother after her heart attack, and she’s advised to take it twice a year.
Read More
7.5
Eliminates skipped beats
5 people found this helpful
This supplement has been a tremendous blessing. No more skipped heartbeats, and it may help lower my high cholesterol as well.
Read More
7.5
Effective for cholesterol
3 people found this helpful
Quercetin, found in many fruits and vegetables, has been beneficial for me. I've been taking it for over a year, with my recent tests showing decreased LDL cholesterol, blood sugar, and blood pressure. I will continue as it has positively impacted my high cholesterol.
Read More
Frequently Asked Questions
7.5
Effective for cholesterol
3 people found this helpful
Quercetin, found in many fruits and vegetables, has been beneficial for me. I've been taking it for over a year, with my recent tests showing decreased LDL cholesterol, blood sugar, and blood pressure. I will continue as it has positively impacted my high cholesterol.
7.5
Eliminates skipped beats
5 people found this helpful
This supplement has been a tremendous blessing. No more skipped heartbeats, and it may help lower my high cholesterol as well.
7.5
Reduces cholesterol risk
8 people found this helpful
Quercetin is an excellent antioxidant. I took it on my doctor's advice. It protects the brain and heart from damage due to insufficient blood supply, especially with high blood pressure. Quercetin lowers the risk of chronic vascular diseases and helps reduce high cholesterol. My cardiologist recommended it for my mother after her heart attack, and she’s advised to take it twice a year.
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
8
Quercetin potentially aids cholesterol management
We explored the impact of quercetin-3-glucoside on mice with high cholesterol diets. Over 12 weeks, mice were given either low or high cholesterol diets, some supplemented with quercetin.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
4
We investigated the effects of quercetin and rutin on cholesterol levels. In laboratory settings using liver cells, we found that both compounds significantly lowered cholesterol levels. They achieved this by boosting the expression of proteins involved in cholesterol metabolism.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
8
Quercetin shows promise for cholesterol
We explored how quercetin affects heart health in rats with high cholesterol. The study found that quercetin significantly improved lipid profiles and reduced oxidative stress linked to high-cholesterol diets.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
References
- Lee MS, Doo M, Kim Y. Effects of quercetin nanoemulsion on SIRT1 activation and mitochondrial biogenesis in the skeletal muscle of high-fat diet-fed mice. Nutr Res Pract. 2024;18:806. doi:10.4162/nrp.2024.18.6.806
- Jung KM, Yu GR, Kim DH, Lim DW, Park WH. Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13101271
- Lee MS, Kim Y. Effects of Quercetin Nanoemulsion on Cholesterol Efflux and MicroRNA-33/34a Expression in the Liver of Mice Fed with a High-Cholesterol Diet. Prev Nutr Food Sci. 2023;28:271. doi:10.3746/pnf.2023.28.3.271
- Yammine A, Auezova L, Lizard G, Greige-Gerges H. Activity of Na/K- and Ca-ATPases in human erythrocyte membranes: Protocol improvement, relation to cholesterol content, and effects of polyphenols. Biochimie. 2023;212:95. doi:10.1016/j.biochi.2023.04.010
- Liang N, Li YM, He Z, Hao W, Zhao Y, et al. Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration. Molecules. 2021;26. doi:10.3390/molecules26123766
- Oyetayo FL, Akomolafe SF, Ogundumi OA. Anti-hypercholesterolemic potential of diet supplemented with and tubers in high cholesterol fed rats. J Diabetes Metab Disord. 2020;19:1139. doi:10.1007/s40200-020-00615-z
- Donaldson J, Ngema M, Nkomozepi P, Erlwanger K. Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups. J Sci Food Agric. 2019;99:6954. doi:10.1002/jsfa.9984
- Son HY, Lee MS, Chang E, Kim SY, Kang B, et al. Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats. Nutrients. 2019;11. doi:10.3390/nu11020244
- Liu S, You L, Zhao Y, Chang X. Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo. Food Res Int. 2018;107:73. doi:10.1016/j.foodres.2018.02.016
- Castillo RL, Herrera EA, Gonzalez-Candia A, Reyes-Farias M, de la Jara N, et al. Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. Oxid Med Cell Longev. 2018;2018:7239123. doi:10.1155/2018/7239123
- Mbikay M, Mayne J, Sirois F, Fedoryak O, Raymond A, et al. Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas. Mol Nutr Food Res. 2018;62:e1700729. doi:10.1002/mnfr.201700729
- Woo M, Kim M, Noh JS, Park CH, Song YO. Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis. Nutr Res Pract. 2017;11:445. doi:10.4162/nrp.2017.11.6.445
- Khamis AA, Salama AF, Kenawy ME, Mohamed TM. Regulation of hepatic hydroxy methyl glutarate - CoA reductase for controlling hypercholesterolemia in rats. Biomed Pharmacother. 2017;95:1242. doi:10.1016/j.biopha.2017.09.071
- Bhaskar S, Helen A. Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats. Mol Cell Biochem. 2016;423:53.
- Carrasco-Pozo C, Tan KN, Reyes-Farias M, De La Jara N, Ngo ST, et al. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol. 2016;9:229. doi:10.1016/j.redox.2016.08.007
- Kang HJ, Pichiah PBT, Abinaya RV, Sohn HS, Cha YS. Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet. Food Sci Biotechnol. 2016;25:855. doi:10.1007/s10068-016-0141-4
